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A study on the structure and function of the YabG protease of Clostridioides difficile: towards its use as a druggable target
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| 2.11 MB | Adobe PDF |
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Resumo(s)
"Clostridioides difficile is the leading microorganism cause of intestinal disease linked to the use of antibiotics. A strict anaerobe, C. difficile forms oxygen-resistant spores that are the main infectious vehicle. The spore surface, mainly the protein coat and the more external exosporium are also important during the initial stages of infection as these layers govern the attachment of spores to epithelial cells and proper germination in response to certain bile salts. The surface layers incorporate structural proteins as well as proteins that function in a pathway.(...)"
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Palavras-chave
spore assembly, colonization YabG morphogenetic protease cysteine protease