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Synthesis, characterization and antiproliferative activity of iridium organometallic complexes bearing N,N-chelating ligands
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"Platinum-based complexes are included in approximately 50–70 % of chemotherapeutic regimens. However, these drugs cause serious side effects in normal tissues, as well as resistance problems which are associated with therapy failure. Consequently, novel anticancer drugs with improved pharmacological properties are needed. Recently, iridium organometallic complexes have demonstrated good solubility in aqueous solutions, stability and alternative modes of action relative to the conventional chemotherapeutic drugs. This thesis reports the synthesis, characterization and in vitro antiproliferative potential of four iridium half-sandwich complexes [(η5-Cp*)Ir(N,N)Cl][Cl] (where Cp* = pentamethylcyclopentadienyl ligand; N,N = 1,10-phenanthroline-5,6-dione (L1), 6,7-dimethyl-2,3-bis(pyridin-2-yl)quinoxaline (L2), 2-[1-(p-tolyl)-1H-1,2,3-triazol-4-yl]pyridine (L3) or 1,1′-di-p-tolyl-1H,1′H-4,4′-bi(1,2,3-triazole) (L4) bidentate chelating ligands). All complexes were fully characterized by proton and carbon (1H and 13C) Nuclear Magnetic Resonance (NMR) spectroscopy, Electrospray Ionization High-Resolution Mass Spectrometry (ESI-HRMS) and Fourier-Transformed Infrared (FTIR) spectroscopy.(...)"
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cancer selectivity iridium organometallic antiproliferative activity N;N-chelating ligands