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Spike glycoprotein: molecular characterization and inactivation of a key player in SARS-CoV-2 infection
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| 7.82 MB | Adobe PDF |
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Resumo(s)
"The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2), emerged in late 2019 and quickly spread worldwide. So far, over 370 million infections and 5.6 million deaths were reported by the World Health Organization. Although a great effort has been made by the scientific community to study SARS-CoV-2, more research is needed to advance the knowledge on this virus.
SARS-CoV-2 is an enveloped virus and its entry into host cells is mediated by a viral surface protein, the spike glycoprotein (S-protein). This protein is composed of two subunits (S1 and S2) that contain essential domains for the viral entry mechanism, namely the receptor-binding domain (RBD), known to bind to angiotensin-converting enzyme 2 (ACE2) present at the host cells surface, and the fusion peptide (FP), which promotes the fusion between the viral and host cell membranes. However, despite the relevance of the FP for viral entry, its location on the S-protein and amino acid sequence are still unclear.(...)"
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Palavras-chave
SARS-CoV-2 spike-glycoprotein