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Unravelling the catalytic mechanism for NO reduction by a flavodiiron protein from Escherichia coli
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"Flavodiiron proteins (FDPs) have been identified as participants in the response mechanisms to nitrosative and oxidative stresses in strict and facultative anaerobic microorganisms. These proteins are composed of a domain containing the differic catalytic center and another containing an FMN. Escherichia coli, a human pathogen, encodes for a class B FDP (named flavorubredoxin, FlRd), having an extra rubredoxin center. FlRd is the only FDP described to date as having NO as its main substrate. Thus, this work aimed to understand the catalytic mechanism of E. coli FDP reducing NO to generate N2O.(...)"
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Palavras-chave
Diiron center catalytic mechanisms flavodiiron proteins flavorubredoxin nitric oxide