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Understanding how Streptococcus pneumoniae adapts to stresses imposed by innate immunity
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| 1.72 MB | Adobe PDF |
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Resumo(s)
"Streptococcus pneumoniae is a commensal microorganism in the human nasopharynx
that can become pathogenic when invading sterile body regions, leading to difficult-to-treat
infections due to strain diversity and antibiotic resistance. The innate immune response to S.
pneumoniae is primarily driven by phagocytes like macrophages, which generate antimicrobial
reactive oxygen species (ROS) and reactive nitrogen species (RNS). To survive, S. pneumoniae
has evolved mechanisms to resist these stresses and relies heavily on glucose metabolism for
survival at infection sites. While phosphotransferase systems (PTS) are linked to stress resistance
in other Gram-positive bacteria, their role in the pneumococcus remains poorly understood.(...)"
Descrição
Palavras-chave
Streptococcus pneumoniae ressonância magnética nuclear (RMN) stress nitrosativo e oxidativo metabolismo