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Normal appearing white matter and tracts in patients with multiple sclerosis
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Orientador(es)
Resumo(s)
Motivation: Magnetic susceptibility is influenced by myelin concentration, playing a significant role in the pathogenesis of MS as a demyelinating disease. Goal(s): This study aims to investigate normal-appearing-white-matter in MS patients using QSM, focusing on the cortico-spinal tract and optic radiation, to find non-invasive biomarkers of pre-clinical inflammatory activity. Approach: The automated implemented pipeline relies on the acquisition of multiple MR sequences. Several susceptibility histogram properties were considered and correlated with disability scores. Results: A decrease in myelin concentration was detected in MS group, consistently with the pathophysiology. Correlations between susceptibility and clinical disability occur, distinguishing clinical phenotypes and levels of motor impairment. Impact: Studying the normal-appearing-white-matter tracts using QSM reveals decrease in myelin concentration within cortico-spinal tract and optic radiation in MS patients. Variations were observed between different clinical phenotypes and various levels of motor impairment, suggesting biomarkers for early diagnosis and prognosis.
Descrição
Fiscone, C., Panzera, I., Manners, D. N., Bartiromo, F., Vornetti, G., Pollarini, V., Rundo, L., Lodi, R., Zaccagna, F., Castelli, M., Lugaresi, A., & Tonon, C. (2024). Normal appearing white matter and tracts in patients with multiple sclerosis: susceptibility properties and clinical disability evaluation [abstract]. Abstract from 2024 ISMRM & ISMRT Annual Meeting & Exhibition, Singapore. https://archive.ismrm.org/2024/2981.html
Palavras-chave
Multiple Sclerosis SDG 3 - Good Health and Well-being