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Normal appearing white matter and tracts in patients with multiple sclerosis

2024-05-09Documento de conferência Acesso aberto
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dc.contributor.authorFiscone, Cristiana
dc.contributor.authorPanzera, Ivan
dc.contributor.authorManners, David Neil
dc.contributor.authorBartiromo, Fiorina
dc.contributor.authorVornetti, Gianfranco
dc.contributor.authorPollarini, Virginia
dc.contributor.authorRundo, Leonardo
dc.contributor.authorLodi, Raffaele
dc.contributor.authorZaccagna, Fulvio
dc.contributor.authorCastelli, Mauro
dc.contributor.authorLugaresi, Alessandra
dc.contributor.authorTonon, Caterina
dc.contributor.institutionInformation Management Research Center (MagIC) - NOVA Information Management School
dc.contributor.institutionNOVA Information Management School (NOVA IMS)
dc.date.accessioned2024-12-18T18:19:56Z
dc.date.available2024-12-18T18:19:56Z
dc.date.embargoedUntil2026-05-09
dc.date.issued2024-05-09
dc.descriptionFiscone, C., Panzera, I., Manners, D. N., Bartiromo, F., Vornetti, G., Pollarini, V., Rundo, L., Lodi, R., Zaccagna, F., Castelli, M., Lugaresi, A., & Tonon, C. (2024). Normal appearing white matter and tracts in patients with multiple sclerosis: susceptibility properties and clinical disability evaluation [abstract]. Abstract from 2024 ISMRM & ISMRT Annual Meeting & Exhibition, Singapore. https://archive.ismrm.org/2024/2981.html
dc.description.abstractMotivation: Magnetic susceptibility is influenced by myelin concentration, playing a significant role in the pathogenesis of MS as a demyelinating disease. Goal(s): This study aims to investigate normal-appearing-white-matter in MS patients using QSM, focusing on the cortico-spinal tract and optic radiation, to find non-invasive biomarkers of pre-clinical inflammatory activity. Approach: The automated implemented pipeline relies on the acquisition of multiple MR sequences. Several susceptibility histogram properties were considered and correlated with disability scores. Results: A decrease in myelin concentration was detected in MS group, consistently with the pathophysiology. Correlations between susceptibility and clinical disability occur, distinguishing clinical phenotypes and levels of motor impairment. Impact: Studying the normal-appearing-white-matter tracts using QSM reveals decrease in myelin concentration within cortico-spinal tract and optic radiation in MS patients. Variations were observed between different clinical phenotypes and various levels of motor impairment, suggesting biomarkers for early diagnosis and prognosis.en
dc.description.versionauthorsversion
dc.description.versionpublished
dc.format.extent499365
dc.identifier.otherPURE: 104178509
dc.identifier.otherPURE UUID: ca203f55-e162-4456-a96f-98050572eee8
dc.identifier.otherORCID: /0000-0002-8793-1451/work/173063430
dc.identifier.urihttp://hdl.handle.net/10362/176519
dc.identifier.urlhttps://archive.ismrm.org/2024/2981.html
dc.language.isoeng
dc.peerreviewedyes
dc.subjectMultiple Sclerosis
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNormal appearing white matter and tracts in patients with multiple sclerosisen
dc.title.subtitlesusceptibility properties and clinical disability evaluation [abstract]en
dc.typeconference object
degois.publication.title2024 ISMRM & ISMRT Annual Meeting & Exhibition
dspace.entity.typePublication
rcaap.rightsopenAccess

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