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Context dependent expectation signals in behavior and brain
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| 9.12 MB | Adobe PDF |
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Resumo(s)
"We recognize that the world has structure, and take advantage of that to be
prepared to act given what we have done previously in similar situations and the
outcomes of those actions. By interacting with our world, we learn that in different
contexts some actions are more adaptive than others. Thus, once we recognize the
situation that we are in at a given time, we can have some action prepared, a default
plan. The cortico-basal ganglia-thalamo-cortical loop (CBGTC) is thought to be
in charge of the recognition of context, and controlling the expression of behaviors
depending on their expected outcomes, v.g. the amount of vigor to exert in the
execution; and dysregulation of their function are associated with neurological and
psychiatric disorders. Critically, given the circuit connectivity, the output of the basal
ganglia (BG), the subtantia nigra pars reticulata (SNr), is the most direct way that
BG reinforcement-learning like algorithm can use to communicate with cortex, via this
region inhibitory projections to the motor thalamus (MTh). However, little is known
about the population level computations of these regions in the process of preparation
of orienting movements for different reinforcers.(...)"
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Palavras-chave
cortico-basal ganglia-thalamo-cortical loop (CBGTC) basal ganglia subtantia nigra pars reticulata motor thalamus