Basal ganglia-thalamo-cortical interactions during gol-directed behavior

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Context dependent expectation signals in behavior and brain

Publication . Espejo, Mauricio Alejandro Toro; Paton, Joseph

"We recognize that the world has structure, and take advantage of that to be prepared to act given what we have done previously in similar situations and the outcomes of those actions. By interacting with our world, we learn that in different contexts some actions are more adaptive than others. Thus, once we recognize the situation that we are in at a given time, we can have some action prepared, a default plan. The cortico-basal ganglia-thalamo-cortical loop (CBGTC) is thought to be in charge of the recognition of context, and controlling the expression of behaviors depending on their expected outcomes, v.g. the amount of vigor to exert in the execution; and dysregulation of their function are associated with neurological and psychiatric disorders. Critically, given the circuit connectivity, the output of the basal ganglia (BG), the subtantia nigra pars reticulata (SNr), is the most direct way that BG reinforcement-learning like algorithm can use to communicate with cortex, via this region inhibitory projections to the motor thalamus (MTh). However, little is known about the population level computations of these regions in the process of preparation of orienting movements for different reinforcers.(...)"

2024-07-03Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

OE

Número da atribuição

PD/BD/114275/2016