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Towards the development of a 3D cell model to study interactions between glioma cells and microglia
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 6.6 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"Gliomas are central nervous system tumors with glial origin. A subset of aggressive, highgrade gliomas, which includes glioblastoma (GBM) and several pediatric gliomas, is characterized
by immunosuppressive tumor microenvironments (TMEs). These immunosuppressive TMEs
were recently associated with increased tumorigenicity and reduced effectiveness of
immunotherapies. The molecular crosstalk between cancer and non-cancer cells (e.g., microglia,
astrocytes) establishes and sustains the immunosuppressive TME. However, the molecular
mechanisms underlying immunosuppression in different glioma subtypes are not well described,
mainly due to the lack of adequate experimental models to address them. Most glioma cell models
fail to include the different cell types of the TME. (...)"
Descrição
Palavras-chave
gliomas microglia tumor microenvironment immunosuppression
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.