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DISCOVERING NOVEL PSEUDOMONAS AERUGINOSA SMALL NON-CODING RNAs INVOLVED IN BIOFILM AND ANTIBIOTIC RESISTANCE MECHANISMS
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Resumo(s)
"Pseudomonas aeruginosa is an opportunistic pathogen capable of infecting
immunocompromised patients, especially patients with cystic fibrosis. When left
untreated, infections result in lung failure and the death of patients. P. aeruginosa is very
difficult to treat due to its strong resistance to several classes of antibiotics, as well as its
ability to develop into multidrug-resistant (MDR) bacteria and form biofilms.
Consequently, it is essential to develop alternative strategies to combat antibiotic
resistance, such as therapies based on small RNAs (sRNAs). These molecules play an
important role in gene expression and have been shown to affect antibiotic resistance and
sensitivity in P. aeruginosa. However, knowledge about sRNAs in this Gram-negative
bacterium is still very limited.(...)"
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Palavras-chave
Pseudomonas aeruginosa PAO1 Small RNAs Antibiotic resistance Biofilms