DISCOVERING NOVEL PSEUDOMONAS AERUGINOSA SMALL NON-CODING RNAs INVOLVED IN BIOFILM AND ANTIBIOTIC RESISTANCE MECHANISMS

Abstract

"Pseudomonas aeruginosa is an opportunistic pathogen capable of infecting immunocompromised patients, especially patients with cystic fibrosis. When left untreated, infections result in lung failure and the death of patients. P. aeruginosa is very difficult to treat due to its strong resistance to several classes of antibiotics, as well as its ability to develop into multidrug-resistant (MDR) bacteria and form biofilms. Consequently, it is essential to develop alternative strategies to combat antibiotic resistance, such as therapies based on small RNAs (sRNAs). These molecules play an important role in gene expression and have been shown to affect antibiotic resistance and sensitivity in P. aeruginosa. However, knowledge about sRNAs in this Gram-negative bacterium is still very limited.(...)"