A carregar...
Publicação
Elucidating the physiological role of the DsrJ cytochrome in dissimilatory sulfate metabolism
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 6.67 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"The increase of sulfidogenic (sulfide-producing) bacteria in the human gut, as a result of
dysbiosis, is often associated with chronic inflammatory disorders. The pathogenesis of sulfidogenic
bacteria is mainly due to the toxicity of their main metabolic product, sulfide. To prevent the
development of such diseases, it is crucial to understand the energy metabolism of these bacteria.
Desulfovibrio vulgaris Hildenborough, a sulfate-reducing bacterium that is a member of the human gut
microbiota, is one of the best-studied model organisms for the dissimilatory reduction of sulfate to
sulfide. Nonetheless, its energy-conserving mechanisms are still not fully understood, particularly, the
function of the widely conserved DsrMKJOP transmembrane complex. The Dsr complex is likely
involved in the reduction of the DsrC-trisulfide with the concomitant production of sulfide, through the
DsrMK module. However, the function of the DsrJOP module is more puzzling, namely that of its
periplasmic subunit, DsrJ.(...)"
Descrição
Palavras-chave
Sulfate-reducing organisms Dissimilatory sulfate reduction Respiratory membrane complexes DsrMKJOP