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Superoxide reductases: unravelling catalytic determinants through natural and site directed mutants
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Resumo(s)
"Superoxide reductases (SOR) are non-heme iron enzymes able to catalyze the
one-electron reduction of superoxide (O •), producing hydrogen peroxide (HO), with
the assistance of an electron donor (usually a rubredoxin). This family of enzymes is
usually divided into two classes: 2Fe-SOR, if they have two iron sites – centre I,
similar to that found in desulforedoxin with the iron being coordinated by four
cysteines; and centre II, the catalytic site, where the iron is coordinated by four
equatorial histidines and one axial cysteine; or 1Fe-SOR, containing only the catalytic
centre II.(...)"
Descrição
Palavras-chave
Superoxide reductases 2Fe-SOR 1Fe-SOR Korarchaeum cryptofilum