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Publicação
THE IMPACT OF DEFECTIVE HOST CELL GLYCOSYLATION IN BACTERIAL INFECTION
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| 2.93 MB | Adobe PDF |
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Orientador(es)
Resumo(s)
"Bacterial infections are a growing concern within medicine, in particular for vulnerable populations. This thesis delves with the crucial role of host glycans in host-pathogen interactions, that serve as beacon targets for tissue recognition and allow adhesion by pathogens, while functioning as sentinels, driving the host’s immune response.
Congenital Disorders of Glycosylation are a group of rare diseases resulting from defects in cell glycosylation. PMM2-CDG, the most prevalent CDG, presents a deficit in N-glycosylation and is mainly known for its neurological involvement. Still, PMM2-CDG has almost 20% pediatric mortality associated with infection. Recent studies showed patients have higher propensity to respiratory, gastrointestinal, and severe infections in PMM2-CDG, but the affected immune mechanisms are still unknown.(...)"
Descrição
Palavras-chave
Congenital Disorders of Glycosylation PMM2-CDG immune response bacterial infection and adhesion
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa