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Unlocking Viral Entry: The Key Role of Fusion Proteins
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 109.06 MB | Adobe PDF |
Orientador(es)
Resumo(s)
"Viral infections are a substantial global health concern, affecting millions of individuals
annually. The initial stage of infection involves viral entry, a process characterized by
intricate mechanisms that remain poorly understood. In this thesis, we employ molecular
dynamics simulations to elucidate the complex mechanisms that allow for the entry of
enveloped viruses into our cells. To achieve this we focused on the existing gaps in the
literature concerning the role of fusion proteins in ensuring efficient viral infection, with
specific attention directed towards events associated with target cell receptor recognition
and membrane fusion. This was studied by analyzing both the SARS-CoV-2 and
parainfluenza 5 viruses.(...)"
Descrição
Palavras-chave
Fusion proteins Molecular Dynamics simulations Fusion peptide Receptor binding domain