Publicação
Unlocking Viral Entry: The Key Role of Fusion Proteins
| datacite.subject.fos | Ciências Naturais | pt_PT |
| dc.contributor.advisor | Soares, Cláudio M. | |
| dc.contributor.advisor | Lousa, Diana | |
| dc.contributor.advisor | Melo, Manuel | |
| dc.contributor.author | de Oliveira Farinha Fidalgo Valério, Mariana | |
| dc.date.accessioned | 2024-02-07T02:09:40Z | |
| dc.date.available | 2024-12-31T01:31:30Z | |
| dc.date.issued | 2023-12-14 | |
| dc.date.submitted | 2023-12-01 | |
| dc.description.abstract | "Viral infections are a substantial global health concern, affecting millions of individuals annually. The initial stage of infection involves viral entry, a process characterized by intricate mechanisms that remain poorly understood. In this thesis, we employ molecular dynamics simulations to elucidate the complex mechanisms that allow for the entry of enveloped viruses into our cells. To achieve this we focused on the existing gaps in the literature concerning the role of fusion proteins in ensuring efficient viral infection, with specific attention directed towards events associated with target cell receptor recognition and membrane fusion. This was studied by analyzing both the SARS-CoV-2 and parainfluenza 5 viruses.(...)" | pt_PT |
| dc.identifier.tid | 101762160 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10362/163204 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | SFRH/BD/148542/2019 | pt_PT |
| dc.subject | Fusion proteins | pt_PT |
| dc.subject | Molecular Dynamics simulations | pt_PT |
| dc.subject | Fusion peptide | pt_PT |
| dc.subject | Receptor binding domain | pt_PT |
| dc.title | Unlocking Viral Entry: The Key Role of Fusion Proteins | pt_PT |
| dc.title.alternative | The importance of viral fusion protein in target cell recognition and viral fusion | pt_PT |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| rcaap.embargofct | Artigos por publicar | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | doctoralThesis | pt_PT |
| thesis.degree.name | Dissertation presented to obtain the PhD degree in Molecular Biosciences | pt_PT |