Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/16107
Título: Nanocomposite polymer beads for cell detection
Autor: Jacinto, João Paulo Palma
Orientador: Rodríguez- Abreu, Carlos
Borges, João Paulo
Palavras-chave: Circulating tumor cells
Nano-emulsion
Membrane emulsification
Solvent evaporation
Nanocomposite polymer beads
Magnetoresistive platform
Data de Defesa: 2015
Resumo: Circulating tumor cells (CTCs) may induce metastases when detached from the primary tumor. The numbers of these cells in blood offers a valuable prognostic indication. Magnetoresistive sensing is an attractive option for CTC counting. In this technique, cells are labeled with nancomposite polymer beads that provide the magnetic signal. Bead properties such as size and magnetic content must be optimized in order to be used as a detection tool in a magnetoresistive platform. Another important component of the platform is the magnet required for proper sensing. Both components are addressed in this work. Nanocomposite polymer beads were produced by nano-emulsion and membrane emulsification. Formulations of the oil phase comprising a mixture of aromatic monomers and iron oxide were employed. The effect of emulsifier (surfactant) concentration on bead size was studied. Formulations of polydimethilsiloxane (PDMS) with different viscosities were also prepared with nano-emulsion method resulting in colloidal beads. Polycaprolactone (PCL) beads were also synthetized by the membrane emulsification method. The beads were characterized by different techiques such as dynamic light scattering (DLS), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). Additionally, the magnet dimensions of the platform designed to detect CTCs were optimized through a COMSOL multiphysics simulation.
URI: http://hdl.handle.net/10362/16107
Designação: Mestrado em Engenharia de Micro e Nanotecnologias
Aparece nas colecções:FCT: DCM - Dissertações de Mestrado

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