Nanomedicine-based strategies to target and modulate the tumor microenvironment

Mendes, Bárbara B.; Sousa, Diana P.; Conniot, João; Conde, João

doi:https://doi.org/10.1016/j.trecan.2021.05.001

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/154245

Título:	Nanomedicine-based strategies to target and modulate the tumor microenvironment
Autor:	Mendes, Bárbara B. Sousa, Diana P. Conniot, João Conde, João
Palavras-chave:	modulation nanotechnology targeting, therapy tumor microenvironment Oncology Cancer Research SDG 3 - Good Health and Well-being
Data:	Set-2021
Resumo:	The interest in nanomedicine for cancer theranostics has grown significantly over the past few decades. However, these nanomedicines need to overcome several physiological barriers intrinsic to the tumor microenvironment (TME) before reaching their target. Intrinsic tumor genetic/phenotypic variations, along with intratumor heterogeneity, provide different cues to each cancer type, making each patient with cancer unique. This brings additional challenges in translating nanotechnology-based systems into clinically reliable therapies. To develop efficient therapeutic strategies, it is important to understand the dynamic interactions between TME players and the complex mechanisms involved, because they constitute invaluable targets to dismantle tumor progression. In this review, we discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines.
Descrição:	Funding Information: The authors acknowledge financial support from Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). Funding Information: The authors acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia/ Minist?rio da Ci?ncia, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). None declared by authors. Publisher Copyright: © 2021 Elsevier Inc.
Peer review:	yes
URI:	http://hdl.handle.net/10362/154245
DOI:	https://doi.org/10.1016/j.trecan.2021.05.001
ISSN:	2405-8033
Aparece nas colecções:	NMS: ToxOmics - Artigos em revista internacional com arbitragem científica

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