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Nanomedicine-based strategies to target and modulate the tumor microenvironment

2021-09Recensão Acesso aberto
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dc.contributor.authorMendes, Bárbara B.
dc.contributor.authorSousa, Diana P.
dc.contributor.authorConniot, João
dc.contributor.authorConde, João
dc.contributor.authorConde, João
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblCell Press
dc.date.accessioned2023-06-21T22:18:39Z
dc.date.available2023-06-21T22:18:39Z
dc.date.issued2021-09
dc.descriptionFunding Information: The authors acknowledge financial support from Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). Funding Information: The authors acknowledge financial support from Funda??o para a Ci?ncia e a Tecnologia/ Minist?rio da Ci?ncia, Tecnologia, e Ensino Superior in the framework of PhD grant 2020.06638.BD (to D.P.S.), and from the European Research Council grant agreement No 848325 (J.C. for the ERC Starting Grant). None declared by authors. Publisher Copyright: © 2021 Elsevier Inc.
dc.description.abstractThe interest in nanomedicine for cancer theranostics has grown significantly over the past few decades. However, these nanomedicines need to overcome several physiological barriers intrinsic to the tumor microenvironment (TME) before reaching their target. Intrinsic tumor genetic/phenotypic variations, along with intratumor heterogeneity, provide different cues to each cancer type, making each patient with cancer unique. This brings additional challenges in translating nanotechnology-based systems into clinically reliable therapies. To develop efficient therapeutic strategies, it is important to understand the dynamic interactions between TME players and the complex mechanisms involved, because they constitute invaluable targets to dismantle tumor progression. In this review, we discuss the latest nanotechnology-based strategies for cancer diagnosis and therapy as well as the potential targets for the design of future anticancer nanomedicines.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent16
dc.format.extent1545091
dc.identifier.doi10.1016/j.trecan.2021.05.001
dc.identifier.issn2405-8033
dc.identifier.otherPURE: 33428173
dc.identifier.otherPURE UUID: e1bd4218-c0c2-44c0-adce-b33348d96120
dc.identifier.otherScopus: 85110014003
dc.identifier.otherPubMed: 34090865
dc.identifier.otherWOS: 000686370700005
dc.identifier.urihttp://hdl.handle.net/10362/154245
dc.identifier.urlhttps://www.scopus.com/pages/publications/85110014003
dc.language.isoeng
dc.peerreviewedyes
dc.subjectmodulation
dc.subjectnanotechnology
dc.subjecttargeting, therapy
dc.subjecttumor microenvironment
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNanomedicine-based strategies to target and modulate the tumor microenvironmenten
dc.typereview
degois.publication.firstPage847
degois.publication.issue9
degois.publication.lastPage862
degois.publication.titleTrends in Cancer
degois.publication.volume7
dspace.entity.typePublication
person.familyNameConde
person.givenNameJoão
person.identifier807432
person.identifier.ciencia-idA71C-B10E-255E
person.identifier.orcid0000-0001-8422-6792
person.identifier.ridF-2231-2011
person.identifier.scopus-author-id56992468300
rcaap.rightsopenAccess
relation.isAuthorOfPublication33ca4178-1b25-4b5e-ae16-b2500abe4c58
relation.isAuthorOfPublication.latestForDiscovery33ca4178-1b25-4b5e-ae16-b2500abe4c58

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