Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/14098
Título: Diffusional kurtosis imaging using a fast heuristic constrained linear least squares algorithm: a plugin for OsiriX
Autor: Mesquita, Nuno Maria Sampaio
Orientador: Fonseca, José
Santinha, João
Palavras-chave: Magnetic resonance imaging
Diffusion kurtosis imaging
Diffusion tensor imaging
Heuristic constrained linear least squares
Data de Defesa: Set-2014
Resumo: Diffusion Kurtosis Imaging (DKI) is a fairly new magnetic resonance imag-ing (MRI) technique that tackles the non-gaussian motion of water in biological tissues by taking into account the restrictions imposed by tissue microstructure, which are not considered in Diffusion Tensor Imaging (DTI), where the water diffusion is considered purely gaussian. As a result DKI provides more accurate information on biological structures and is able to detect important abnormalities which are not visible in standard DTI analysis. This work regards the development of a tool for DKI computation to be implemented as an OsiriX plugin. Thus, as OsiriX runs under Mac OS X, the pro-gram is written in Objective-C and also makes use of Apple’s Cocoa framework. The whole program is developed in the Xcode integrated development environ-ment (IDE). The plugin implements a fast heuristic constrained linear least squares al-gorithm (CLLS-H) for estimating the diffusion and kurtosis tensors, and offers the user the possibility to choose which maps are to be generated for not only standard DTI quantities such as Mean Diffusion (MD), Radial Diffusion (RD), Axial Diffusion (AD) and Fractional Anisotropy (FA), but also DKI metrics, Mean Kurtosis (MK), Radial Kurtosis (RK) and Axial Kurtosis (AK).The plugin was subjected to both a qualitative and a semi-quantitative analysis which yielded convincing results. A more accurate validation pro-cess is still being developed, after which, and with some few minor adjust-ments the plugin shall become a valid option for DKI computation
URI: http://hdl.handle.net/10362/14098
Designação: Dissertação
Aparece nas colecções:FCT: DF - Dissertações de Mestrado

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