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Publicação
Exploring the synergy between copper and antifungals
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| 5.01 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
"Invasive fungal infections (IFIs) are a major health concern, affecting many people worldwide and causing more than 1.2 million deaths per year. Most hospital-acquired IFIs are caused by Candida species, which are natural colonizers of the human microbiota, but can become pathogenic under specific medical contexts. Candida albicans accounts for approximately 50% of all clinical isolates from patients with invasive candidiasis. However, the widespread use of antifungal therapy has favoured the selection of Candida species that are less susceptible to antifungals, such as Candida glabrata. In this sense, finding novel antifungal targets or/and improving the efficacy of currently available drugs is of urgent and utmost importance.(...)".
Descrição
Palavras-chave
antifungals fluconazole pathogenic Yeast copper
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de tecnologia Química e Biológica António Xavier