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Influence of Ferredoxin, Iron-Sulfur Carrier and Cobalamin Importer Overexpression on the Production of High-value Products by Escherichia coli
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Resumo(s)
"One of the problems in antibiotics production is the difficulty of their synthesis or low yield
in the case of complex biological molecules. They have complex biosynthetic pathways, where
cobalamin-dependent SAM enzymes play a pivotal role, with an Fe-S cluster in their structure and
the necessity of secondary electron transfer proteins for their activity, making the production
improvement difficult. An example of these compounds are fosfomycin (Fom3 enzyme), a broadspectrum
antibiotic, and thiostrepton (TsrM enzyme), a Gram-positive antibiotic with anticancer
properties, both naturally produced by Streptomyces sp..(...)"
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Cobalamin-dependent SAM enzymes Ferredoxin SufUT proteins Btu proteins