Establishment of bioengineered glucose-responsive nanoparticles for type 2 diabetes mellitus therapy

Fonseca, Filipa Ribeiro da

http://hdl.handle.net/10362/130074

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Autores

Fonseca, Filipa Ribeiro da

Resumo(s)

"Type 2 diabetes mellitus (T2DM) is one of the biggest health problems in the world. Glucagon like peptide-1, an endogenous gastrointestinal incretin hormone that stimulates insulin secretion, is considered an attractive therapeutic agent for T2DM treatment. Nevertheless, its short half-life has led to the development of longer half-life GLP-1 analogues, as exenatide. Still, current dosage forms for exenatide delivery are not exempt of shortcomings. Nanotechnology-based systems may offer several advantages over conventional dosage forms for drug delivery.(...)"

Descrição

Dissertation presented to obtain the Master degree in Biochemistry for Health

Palavras-chave

Closed-loop delivery system Glucagon like peptide-1 analogues glucose-oxidase pH-sensitive nanoparticles

URI

http://hdl.handle.net/10362/130074

Editora

Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier

Coleções

ITQB: NBPT- MA Dissertation

Licença CC

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