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Image Quality Improvement of Medical Images using Deep Learning for Computer-aided Diagnosis
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Orientador(es)
Resumo(s)
Retina image analysis is an important screening tool for early detection of multiple dis eases such as diabetic retinopathy which greatly impairs visual function. Image analy sis and pathology detection can be accomplished both by ophthalmologists and by the
use of computer-aided diagnosis systems. Advancements in hardware technology led to
more portable and less expensive imaging devices for medical image acquisition. This
promotes large scale remote diagnosis by clinicians as well as the implementation of
computer-aided diagnosis systems for local routine disease screening. However, lower cost equipment generally results in inferior quality images. This may jeopardize the
reliability of the acquired images and thus hinder the overall performance of the diagnos tic tool. To solve this open challenge, we carried out an in-depth study on using different
deep learning-based frameworks for improving retina image quality while maintaining
the underlying morphological information for the diagnosis. Our results demonstrate
that using a Cycle Generative Adversarial Network for unpaired image-to-image trans lation leads to successful transformations of retina images from a low- to a high-quality
domain. The visual evidence of this improvement was quantitatively affirmed by the two
proposed validation methods. The first used a retina image quality classifier to confirm a
significant prediction label shift towards a quality enhance. On average, a 50% increase
of images being classified as high-quality was verified. The second analysed the perfor mance modifications of a diabetic retinopathy detection algorithm upon being trained
with the quality-improved images. The latter led to strong evidence that the proposed
solution satisfies the requirement of maintaining the images’ original information for
diagnosis, and that it assures a pathology-assessment more sensitive to the presence of
pathological signs. These experimental results confirm the potential effectiveness of our
solution in improving retina image quality for diagnosis. Along with the addressed con tributions, we analysed how the construction of the data sets representing the low-quality
domain impacts the quality translation efficiency. Our findings suggest that by tackling
the problem more selectively, that is, constructing data sets more homogeneous in terms
of their image defects, we can obtain more accentuated quality transformations.
Descrição
Palavras-chave
Generative Models Diabetic Retinopathy Retina Image Quality