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Publicação
Efeito inibitório de compostos naturais em culturas planctónicas e biofilmes de Candida
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| 1.9 MB | Adobe PDF |
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Orientador(es)
Resumo(s)
"The incidence and prevalence of invasive fungal infections has been increasing, especially in immunocompromised and hospitalized patients with serious underlying diseases. Several species of Candida are the main etiological agents of these types of infection, particularly Candida albicans. Pathogenicity of Candida species is attributed to several virulence factors including the capability to form biofilms, which show higher levels of antifungal resistance. The use of natural products, such as extracts of plant’s essential oils, have been explored as alternative antifungal therapeutic strategies. However, these naturally occurring compounds have not yet found any established role in the formulation of conventional pharmaceutical antifungal products. In addition, most published works assessed the antifungal activity of these compounds in planktonic yeast cells, existing a knowledge gap on the potential action these compounds may have against yeast biofilms.This work aimed to assess the antifungal activity of extracts of essential oils, and the eventual synergy these compounds may have with conventional antifungal drugs, against isolates of Candida growing as planktonic cultures and as biofilms.(...)"
Descrição
Palavras-chave
natural products Candida
Contexto Educativo
Citação
Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier