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Characterization of biological and metabolic responses to pH changes in a commensal Staphylococcus epidermidis strain

2019-11-29Dissertação de mestrado Acesso aberto
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dc.contributor.authorSantos, Susana Isabel Duarte dos
dc.date.accessioned2022-01-02T16:02:23Z
dc.date.available2022-11-30T01:34:03Z
dc.date.issued2019-11-29
dc.description.abstract"Staphylococcus epidermidis is a Gram-positive commensal bacterium found mainly in mucous membranes but also in sebaceous areas. It is considered an opportunistic pathogen associated with nosocomial infections. Indeed, S. epidermidis is the main cause of coagulase negative staphylococci infections associated with medical devices. This thesis aims to understand the impact of pH conditions which mimic the skin pH (5.5) and blood pH (7.4) in a S. epidermidis commensal strain (19N) biological processes and metabolic pathways. Proteomic studies were realized by nanoscale liquid chromatography-tandem mass spectrometry (nano LC-MS/MS) and metabolomic studies through nuclear magnetic resonance (NMR) in the whole cellular extract."pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10362/130114
dc.language.isoengpt_PT
dc.publisherUniversidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavierpt_PT
dc.subjectStaphylococcus epidermidispt_PT
dc.subjectinfection processpt_PT
dc.subjectproteomicpt_PT
dc.subjectmetabolomicpt_PT
dc.titleCharacterization of biological and metabolic responses to pH changes in a commensal Staphylococcus epidermidis strainpt_PT
dc.typemaster thesis
dspace.entity.typePublication
oaire.citation.conferencePlaceOeiras. Portugalpt_PT
rcaap.embargofctArtigos por publicarpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typemasterThesispt_PT

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ITQB: PNMO - MA Dissertations