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Sensory and motor representations in the inferior olive of larval zebrafish
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"The olivo-cerebellar system plays a pivotal role in sensorimotor con- trol and coordination in vertebrates. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning in the cerebellum. Even though this process has been extensively studied over the last five decades, it re- mains unclear whether the nature of IO signals is more sensory, motor or both. In this thesis we address the nature of sensory and motor rep- resentations in the IO of larval zebrafish and investigate their potential interactions and spatial organization. We presented a set of visual stimuli to larval zebrafish and recorded calcium activity in genetically identified IO neurons with a 2-photon microscope while simultaneously tracking the fishes’ eye and tail movements. We found that most IO responses were binocular, direction selective and spatially organized.(...)"
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olivo-cerebellar system larval zebrafish