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Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells

2013-12Artigo científico Acesso aberto
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dc.contributor.authorOliveira, E.
dc.contributor.authorSantos, H. M.
dc.contributor.authorGarcia-Pardo, Javier
dc.contributor.authorDiniz, M.
dc.contributor.authorLorenzo, Julia
dc.contributor.authorRodríguez-González, B.
dc.contributor.authorCapelo, J. L.
dc.contributor.authorLodeiro, C.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionCQFB-REQUIMTE - Centro de Química Fina e Biotecnologia (Lab. Associado REQUIMTE)
dc.contributor.pblFrontiers Media
dc.date.accessioned2018-07-19T22:09:07Z
dc.date.available2018-07-19T22:09:07Z
dc.date.issued2013-12
dc.descriptionAuthors thank Xunta de Galicia (Biomedicine) for the research grant 10CSA383009PR, and Scientific PROTEOMASS Association (Portugal) for financial support. Elisabete Oliveira and Hugo M. Santos thank to MEC-FCT (Portugal), for the post-doctoral grants SRFH/BPD/72557/2010 and SRFH/BPD/73997/2010. Julia Lorenzo thanks to Ministerio de Ciencia e Innovacion (MICINN) of Spain, for grant BIO2010-22321-C02. Authors thank the financial support by REQUIMTE-FCT PEst-C/EQB/LA0006/2013.
dc.description.abstractSilver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. However, their potential toxicity remains unclear. In order to unravel this issue, emissive AgNPs were first synthetized using an inexpensive photochemical method, and then their permeation was assessed in vivo in goldfish and in vitro in human hepatoma cells (HepG2). In addition, the oxidative stress caused by AgNPs was assessed in enzymes such as glutathione-S-transferase (GST), catalase (CAT), and in lipid peroxidation (LPO). This study demonstrates that the smallest sized AgNPs@3 promote the largest changes in gold fish livers, whereas AgNPs@1 were found to be toxic in HEPG2 cells depending on both the size and functionalized/stabilizer ligand. © 2013 Oliveira, Santos, Garcia-Pardo, Diniz, Lorenzo, Rodríguez-González, Capelo and Lodeiro.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2647818
dc.identifier.doi10.3389/fchem.2013.00029
dc.identifier.issn2296-2646
dc.identifier.otherPURE: 2587433
dc.identifier.otherPURE UUID: b357f23d-6265-40c1-a286-24f252fe14e7
dc.identifier.otherRIS: urn:A82A4B3DF2435805F3F6F3E8F2A0A23F
dc.identifier.otherScopus: 84987753775
dc.identifier.otherWOS: 000209678500027
dc.identifier.otherPubMed: 24790957
dc.identifier.otherPubMedCentral: PMC3988373
dc.identifier.otherORCID: /0000-0001-5582-5446/work/46943974
dc.identifier.otherORCID: /0000-0002-6032-8679/work/55907709
dc.identifier.urihttp://hdl.handle.net/10362/42017
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCytotoxicity
dc.subjectFluorescence
dc.subjectGoldfish
dc.subjectHuman hepatoma cells
dc.subjectSilver nanoparticles
dc.titleSynthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cellsen
dc.typejournal article
degois.publication.titleFrontiers in Chemistry
degois.publication.volume1
dspace.entity.typePublication
rcaap.rightsopenAccess

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