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Molecular characterization of clinical isolates of the Mycobacterium abscessus complex circulating in Lisbon
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Autores
Orientador(es)
Resumo(s)
"The Mycobacterium abscessus complex is an emerging pathogen responsible for human
disease. It includes three subspecies closely related: M. abscessus subsp. abscessus, M.
abscessus subsp. massiliense and M. abscessus subsp. bolletii. M. abscessus is a pathogen
known for its broad resistance to antibiotics such as macrolides, aminoglycosides, β-lactams,
and tetracyclines, and the resistance profile is assumed to vary within subspecies. Although
M. abscessus evolved as an environmental bacterium to survive hostile environments is now
in transition to a pathogenic bacteria. In this study, we aim to characterize genotypically a
panel of clinical isolates of M. abscessus complex, collected during 2007 and 2022 in the
Lisbon metropolitan health area. Clinical isolates were identified to subspecies level by using
the commercial identification assay Genotype NTM-DR and by erm(41) DNA sequencing.
Genotype NTM-DR was also used to determine molecular resistance to macrolides and
aminoglycosides. The genetic diversity among the population was studied by M13-
fingerprinting.(...)"
Descrição
Palavras-chave
M. abscessus complex NTM-DR subspecies M13-fingerprinting erm(41)
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.