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From mechanics to thermodynamics of hexameric molecular motors
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"Molecular motors are protein assemblies that convert chemical energy into motion.
This energy conversion can be understood as a transfer between chemical and mechanical
processes, mediated by highly orchestrated conformational changes in protein
structure. These motors are indispensable for all forms of life, sustaining both their
metabolism and spatial organisation. Among them, hexameric ATPases form a broad
and diverse group of molecular machines that play central roles in protein and DNA
manipulation. Despite major advances in biochemistry, biophysics, and structural
biology, the link between conformational changes and energy processing in these proteins
remains poorly understood. This thesis aims to address this gap by integrating
data from protein structures with novel interdisciplinary analytical tools.(...)"
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Molecular motors Protein Strain Analysis RuvB ClpX