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Metagenomic Research of Infectious Diseases in Archaeological Contexts

2022-06-01Artigo científico Acesso aberto
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dc.contributor.authorAlves-Cardoso, Francisca
dc.contributor.authorPalomo-Díez, Sara
dc.contributor.authorConde, Alejandro Alonso
dc.contributor.authorGomes, Cláudia
dc.contributor.authorCasimiro, Silvia
dc.contributor.authorSilva, Rodrigo Banha da
dc.contributor.authorArroyo-Pardo, Eduardo
dc.contributor.institutionCentro em Rede de Investigação em Antropologia (CRIA - NOVA FCSH)
dc.contributor.institutionDepartamento de História (DH)
dc.contributor.institutionInstituto de Estudos Medievais (IEM)
dc.contributor.institutionCHAM - Centro de Humanidades
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-07-26T22:25:16Z
dc.date.available2022-07-26T22:25:16Z
dc.date.issued2022-06-01
dc.description
dc.description.abstractSyphilis is one of the most exciting diseases explored in paleopathology and, therefore, tracing back its origin and development has provided a prolific debate. The combination of paleopathological data with historical sources, iconography, and archaeological contexts were the primary sources used to reconstruct its historical path. However, there are some limitations to paleopathological diagnosis due to the nature of bone reaction to stimuli. In addition, historical sources are subjected to a bias of social and cultural nature and the knowledge of those who wrote them. Hence, ancient DNA analysis offers the possibility of acquiring proof of cause by identifying pathogens in an organism. We undertook a metagenomic study of a skeleton exhumed from the Royal Hospital of All Saints (Portugal), renowned for treating syphilis from the 16th century onwards. The skeleton had previously been diagnosed with syphilis according to paleopathological analysis. However, the metagenomics analysis showed no presence of the pathogen associated with syphilis (i.e., Treponema pallidum) but revealed pathogenic microorganisms related to respiratory diseases (pneumonia), nonspecific bone infections (osteomyelitis), and oral bacterial pathologies as well as Hansen’s disease (also known as leprosy). The results are exciting and demand a reappraisal of the observed bone changes, recontextualizing their characterization as syphilis related. They prove that past reconstruction of health and disease diagnoses based on assessing human osteological remains of known context (such as a syphilitic hospital) may bias interpretations and, therefore, caution is recommended, not forgetting that the absence of evidence is not evidence of absence (in this case of syphilis) in life.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent1326054
dc.identifier.doi10.3390/app12126096
dc.identifier.issn2076-3417
dc.identifier.otherPURE: 45307695
dc.identifier.otherPURE UUID: 1d730727-c35c-4a37-8fd7-c264cb3189de
dc.identifier.otherScopus: 85132772452
dc.identifier.otherORCID: /0000-0001-8386-2009/work/116400598
dc.identifier.otherORCID: /0000-0001-9132-2336/work/116401286
dc.identifier.urihttp://hdl.handle.net/10362/142429
dc.identifier.urlhttps://www.scopus.com/pages/publications/85132772452
dc.identifier.urlhttps://www.mdpi.com/2076-3417/12/12/6096
dc.language.isoeng
dc.peerreviewedyes
dc.relationIF/00127/2014/CP1233/CT0003 info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00127%2F2014%2FCP1233%2FCT0003/PT
dc.relationUIDB/04038/2020 UIDP/04038/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04038%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04038%2F2020/PT
dc.relationCentre for Research in Anthropology
dc.subject16S metagenomics
dc.subjectAncient DNA
dc.subjectBones
dc.subjectHuman remains
dc.subjectLeprosy
dc.subjectMicrobiome
dc.subjectPaleopathology
dc.subjectSyphilis
dc.subjectGeneral Materials Science
dc.subjectInstrumentation
dc.subjectGeneral Engineering
dc.subjectProcess Chemistry and Technology
dc.subjectComputer Science Applications
dc.subjectFluid Flow and Transfer Processes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMetagenomic Research of Infectious Diseases in Archaeological Contextsen
dc.title.subtitleEvidence from the Hospital Real de Todos-os-Santos (Portugal)en
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue12
degois.publication.lastPage15
degois.publication.titleApplied Sciences
degois.publication.volume12
dspace.entity.typePublication
oaire.awardNumberUIDP/04038/2020
oaire.awardTitleCentre for Research in Anthropology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04038%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication296b6af8-a6ec-4ffb-b913-ad41070525b3
relation.isProjectOfPublication.latestForDiscovery296b6af8-a6ec-4ffb-b913-ad41070525b3

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