Publicação
The Role of Biliverdin Reductase A in Malaria
| datacite.subject.fos | Ciências Naturais::Ciências Biológicas | |
| dc.contributor.advisor | Soares, Miguel | |
| dc.contributor.advisor | Martins, Rui | |
| dc.contributor.author | Figueiredo, Ana | |
| dc.date.accessioned | 2026-03-18T17:15:41Z | |
| dc.date.available | 2026-03-18T17:15:41Z | |
| dc.date.issued | 2026-02-06 | |
| dc.date.submitted | 2025-10-13 | |
| dc.description.abstract | "Malaria, a life-threatening disease caused by Plasmodium spp., remains a major global health burden. While considerable progress has been made in characterizing host resistance mechanisms that reduce parasite burden during Plasmodium infection, our understanding of these pathways remains incomplete. Disease tolerance mechanisms that mitigate tissue damage during infection without directly affecting parasite burden are even less well-understood. This PhD thesis explores the hypothesis that biliverdin reductase A (BVRA) and its end product, unconjugated bilirubin, confer host protection against malaria through both resistance and disease tolerance mechanisms.(...)" | por |
| dc.identifier.tid | 101848544 | |
| dc.identifier.uri | http://hdl.handle.net/10362/201621 | |
| dc.language.iso | eng | |
| dc.relation | 2020.04797.BD | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | infection | |
| dc.subject | Plasmodium | |
| dc.subject | Malaria | |
| dc.subject | biliverdin reductase A (BVRA) | |
| dc.subject | resistance | |
| dc.subject | BVRA/bilirubin axis | |
| dc.title | The Role of Biliverdin Reductase A in Malaria | por |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| thesis.degree.name | Dissertation presented to obtain the PhD degree in Molecular Biosciences |