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The Role of Biliverdin Reductase A in Malaria
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Orientador(es)
Resumo(s)
"Malaria, a life-threatening disease caused by Plasmodium spp., remains a major
global health burden. While considerable progress has been made in
characterizing host resistance mechanisms that reduce parasite burden during
Plasmodium infection, our understanding of these pathways remains incomplete.
Disease tolerance mechanisms that mitigate tissue damage during infection
without directly affecting parasite burden are even less well-understood. This PhD
thesis explores the hypothesis that biliverdin reductase A (BVRA) and its end
product, unconjugated bilirubin, confer host protection against malaria through
both resistance and disease tolerance mechanisms.(...)"
Descrição
Palavras-chave
infection Plasmodium Malaria biliverdin reductase A (BVRA) resistance BVRA/bilirubin axis