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Plasmodium simium

2025-07-16Artigo científico Acesso aberto
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dc.contributor.authorDe Albuquerque, Nathalia Rammé M.
dc.contributor.authorLadeia, Winni A.
dc.contributor.authorScalsky, Ryan J.
dc.contributor.authorDwivedi, Ankit
dc.contributor.authorStabler, Thomas C.
dc.contributor.authorRodrigues, Priscila T.
dc.contributor.authorDe Oliveira, Thaís C.
dc.contributor.authorSilva, Joana C.
dc.contributor.authorFerreira, Marcelo U.
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
dc.contributor.institutionIndividual Health Care (IHC)
dc.contributor.pblCambridge University Press
dc.date.accessioned2026-02-16T18:03:01Z
dc.date.available2026-02-16T18:03:01Z
dc.date.issued2025-07-16
dc.descriptionFunding text: This research was supported by grants from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States of America (grant U19 AI089681, subcontract to M.U.F.; grant R01 AI141900 to J.C.S.) and the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (FAPESP; grant 2016/18740-9 to M.U.F.). We also acknowledge post-doctoral FAPESP fellowships from FAPESP to N.R.M.dA. (2022/10056-2 and 2023/12394-5), P.T.R. (2018/03902-9) and T.C.d.O. (2021/01017-0); a doctoral FAPESP scholarship to W.A.L. (2023/15369-1); a senior researcher scholarship from the Conselho Nacional de Desenvolvimento Científico e Tecnológico of Brazil (CNPq; 301011/2019-2) to M.U.F.; and institutional support from the Fundação para a Ciência e Tecnologia of Portugal (FCT), through the projects UID/04413/2020 to the Global Health and Tropical Medicine Research Center and LA-REAL LA/P/0117/2020. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: © 2025 Cambridge University Press. All rights reserved.
dc.description.abstractPlasmodium simium, a parasite of platyrrhine monkeys, is known to cause human malaria outbreaks in Southeast Brazil. It has been hypothesized that, upon the introduction of Plasmodium vivax into the Americas at the time of the European colonization, the human parasite adapted to Neotropical anophelines of the Kerteszia subgenus and to local monkeys, along the Atlantic coast of Brazil, to give rise to a sister species, P. simium. Here, to obtain new insights into the origins and adaptation of P. simium to new hosts, we analysed whole-genome sequence data from 31 P. simium isolates together with a global sequence dataset of 1,086 P. vivax isolates. Population genomic analyses revealed that P. simium comprises a discrete parasite lineage with greatest genetic similarity to P. vivax populations from Latin America especially those from the Amazon Basin of Brazil and to ancient European P. vivax isolates, consistent with Brazil as the most likely birthplace of the species. We show that P. simium displays half the amount of nucleotide diversity of P. vivax from Latin America, as expected from its recent origin. We identified pairs of sympatric P. simium isolates from monkeys and from humans as closely related as meiotic half-siblings, revealing ongoing zoonotic transmission of P. simium. Most critically, we show that P. simium currently causes most, and possibly all, malarial infections usually attributed to P. vivax along the Serra do Mar Mountain Range of Southeast Brazil.en
dc.description.versionpublishersversion
dc.description.versionepub_ahead_of_print
dc.format.extent1183520
dc.identifier.doi10.1017/S0031182025100310
dc.identifier.issn0031-1820
dc.identifier.otherPURE: 130720293
dc.identifier.otherPURE UUID: fc108267-ce8f-4bdf-8082-a6e95710a992
dc.identifier.otherScopus: 105011751250
dc.identifier.otherWOS: 001549489700001
dc.identifier.otherPubMed: 40665206
dc.identifier.otherPubMedCentral: PMC12644964
dc.identifier.otherORCID: /0000-0002-5293-9090/work/205895084
dc.identifier.urihttp://hdl.handle.net/10362/200426
dc.identifier.urlhttps://www.scopus.com/pages/publications/105011751250
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAtlantic Forest
dc.subjectBrazil
dc.subjectmalaria, Plasmodium simium
dc.subjectPlasmodium vivax
dc.subjectpopulation genomics
dc.subjectzoonosis
dc.subjectParasitology
dc.subjectAnimal Science and Zoology
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePlasmodium simiumen
dc.title.subtitleBirth and evolution of a zoonotic malaria parasite speciesen
dc.typejournal article
degois.publication.firstPage848
degois.publication.issue8(SI)
degois.publication.lastPage859
degois.publication.titleParasitology
degois.publication.volume152
dspace.entity.typePublication
rcaap.rightsopenAccess

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