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Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations

2021-03-31Artigo científico Acesso aberto
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dc.contributor.authorLaronha, Helena
dc.contributor.authorCarpinteiro, Inês
dc.contributor.authorPortugal, Jaime
dc.contributor.authorAzul, Ana
dc.contributor.authorPolido, Mário
dc.contributor.authorPetrova, Krasimira T.
dc.contributor.authorSalema-Oom, Madalena
dc.contributor.authorBarahona, Isabel
dc.contributor.authorCaldeira, Jorge
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblMDPI AG
dc.date.accessioned2022-12-02T22:14:06Z
dc.date.available2022-12-02T22:14:06Z
dc.date.issued2021-03-31
dc.descriptionFunding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractCollagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1;-2;-8;-9 and-13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent20
dc.format.extent13029126
dc.identifier.doi10.3390/biomedicines9040366
dc.identifier.issn2227-9059
dc.identifier.otherPURE: 45575058
dc.identifier.otherPURE UUID: a5b1ab2e-66ed-4d3c-8ff2-5cb54bf97bd8
dc.identifier.otherScopus: 85104406009
dc.identifier.otherWOS: 000642809200001
dc.identifier.otherPubMed: 33807479
dc.identifier.otherPubMedCentral: PMC8065691
dc.identifier.urihttp://hdl.handle.net/10362/145949
dc.identifier.urlhttps://www.scopus.com/pages/publications/85104406009
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-BMA%2F122444%2F2010/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/9876 - Politécnicos/SAICT-POL%2F24288%2F2016/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationApplied Molecular Biosciences Unit
dc.relationEgas Moniz Interdisciplinary Research Center
dc.subjectCytotoxicity
dc.subjectInhibitors of matrix metalloproteinases
dc.subjectMatrix
dc.subjectMetalloproteinases
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.titlePolymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorationsen
dc.typejournal article
degois.publication.issue4
degois.publication.titleBiomedicines
degois.publication.volume9
dspace.entity.typePublication
oaire.awardNumberSAICT-POL/24288/2016
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUID/Multi/04378/2019
oaire.awardNumberUIDB/04585/2020
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleEgas Moniz Interdisciplinary Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9876 - Politécnicos/SAICT-POL%2F24288%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04585%2F2020/PT
oaire.fundingStream9876 - Politécnicos
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
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relation.isProjectOfPublication.latestForDiscoveryadc84c24-ba1d-4bcd-b753-2128ce9a5faa

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