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A Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cells

2020-11-17Artigo científico Acesso aberto
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dc.contributor.authorSeco, Pedro
dc.contributor.authorMartins, Gabriel G.
dc.contributor.authorJacinto, António
dc.contributor.authorJacinto, Antonio
dc.contributor.authorTavares, Ana Teresa
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblFrontiers Media
dc.date.accessioned2020-12-15T05:28:35Z
dc.date.available2020-12-15T05:28:35Z
dc.date.issued2020-11-17
dc.descriptionFUNDING This work was supported by the FCT – Fundação para a Ciência e a Tecnologia, I.P. (PTDC/BTM-SAL/29377/2017) and iNOVA4Health (UID/Multi/04462/2019). The Advanced Imaging Facility of the Instituto Gulbenkian de Ciência was supported by national Portuguese funding co-financed by the Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and FCT (PPBI-POCI-01- 0145-FEDER-022122). AT was funded by the FCT in the context of a program contract under “Norma Transitória” (DL57/2016 of 29 August, as amended by DL57/2017 of 19 July).
dc.description.abstractDuring early embryogenesis, the hemogenic endothelium of the developing dorsal aorta is the main source of definitive hematopoietic stem cells (HSCs), which will generate all blood cell lineages of the adult organism. The hemogenic endothelial cells (HECs) of the dorsal aorta are known to arise from the splanchnic lateral plate mesoderm. However, the specific cell lineages and developmental paths that give rise to aortic HECs are still unclear. Over the past half a century, the scientific debate on the origin of aortic HECs and HSCs has largely focused on two potential and apparently alternative birthplaces, the extraembryonic yolk sac blood islands and the intraembryonic splanchnic mesoderm. However, as we argue, both yolk sac blood islands and aortic HECs may have a common hemangioblastic origin. Further insight into aortic HEC development is being gained from fate-mapping studies that address the identity of progenitor cell lineages, rather than their physical location within the developing embryo. In this perspective article, we discuss the current knowledge on the origin of aortic HECs with a particular focus on the evidence provided by studies in the avian embryo, a model that pioneered the field of developmental hematopoiesis.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1648971
dc.identifier.doi10.3389/fcell.2020.605274
dc.identifier.otherPURE: 26838731
dc.identifier.otherPURE UUID: 9a666fb7-fc2c-4c96-bf6a-28b5a12f74d6
dc.identifier.otherScopus: 85097196294
dc.identifier.otherORCID: /0000-0002-4193-6089/work/85242915
dc.identifier.otherWOS: 000594400800001
dc.identifier.otherPubMed: 33330505
dc.identifier.urihttp://hdl.handle.net/10362/108670
dc.identifier.urlhttps://www.scopus.com/pages/publications/85097196294
dc.language.isoeng
dc.peerreviewedyes
dc.subjectavian embryo
dc.subjectdorsal aorta
dc.subjecthemangioblast
dc.subjecthemogenic endothelium
dc.subjectlineage-tracing
dc.subjectyolk sac
dc.subjectDevelopmental Biology
dc.subjectCell Biology
dc.titleA Bird’s Eye View on the Origin of Aortic Hemogenic Endothelial Cellsen
dc.typejournal article
degois.publication.titleFrontiers in Cell and Developmental Biology
degois.publication.volume8
dspace.entity.typePublication
person.familyNameJacinto
person.givenNameAntonio
person.identifier.ciencia-idDF15-1DEB-A48C
person.identifier.orcid0000-0002-4193-6089
person.identifier.ridF-5729-2013
person.identifier.scopus-author-id55880355900
rcaap.rightsopenAccess
relation.isAuthorOfPublication37ff3a19-e7d7-4c9f-af75-fade2f9aa9d1
relation.isAuthorOfPublication.latestForDiscovery37ff3a19-e7d7-4c9f-af75-fade2f9aa9d1

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