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COMPUTATIONAL DESIGN OF MINIPROTEIN AND MONOBODY BINDERS FOR HEMAGGLUTININ OF H5N1
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| In March 2024, the highly pathogenic avian influenza (HPAI) H5N1 was first reported to spill over into dairy cattle with sustained cattle to cattle transmission across multiple states in the U.S.A. This event, along with reverse spillovers into poultry and other mammals, including humans, raised concerns about mammalian adaptation and the potential for increased zoonotic risk. The primary concern is a shift in hemagglutinin (HA) receptor specificity from avian-type α2-3 sialic acids to human-type α2-6, which could facilitate efficient human infection and onward transmission. Hemagglutinin is central to this risk because it mediates receptor binding and entry; therefore, conserved HA sites represent logical antiviral targets. | 9.46 MB | Adobe PDF |
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Resumo(s)
In March 2024, the highly pathogenic avian influenza (HPAI) H5N1 was first reported to spill over into dairy cattle with sustained cattle to cattle transmission across multiple states in the U.S.A. This event, along with reverse spillovers into poultry and other
mammals, including humans, raised concerns about mammalian adaptation and the potential for increased zoonotic risk. The primary concern is a shift in hemagglutinin (HA) receptor specificity from avian-type α2-3 sialic acids to human-type α2-6, which could facilitate efficient human infection and onward transmission. Hemagglutinin is central to this risk because it mediates receptor binding and entry; therefore, conserved HA sites represent logical antiviral targets.
Descrição
Palavras-chave
H5N1 Hemagglutinin Molecular Dynamics (MD) Simulations De novo Protein Design Miniprotein Monobody