Publicação
the liver endoplasmic reticulum in malaria liver infection
| dc.contributor.advisor | Mota, Maria Manuel | |
| dc.contributor.advisor | Henriques, Adriano Oliveira | |
| dc.contributor.author | Inácio, Patrícia Irene da Silva | |
| dc.date.accessioned | 2015-01-16T16:33:36Z | |
| dc.date.available | 2016-01-31T01:30:10Z | |
| dc.date.issued | 2013-12 | |
| dc.date.submitted | 2015-01 | |
| dc.description.abstract | Malaria, a disease caused by Plasmodium, represents a major health problem with a still disconcertingly high mortality rate (655 000 malaria deaths were estimated by the World Health Organization in 2012), mainly in Africa [1]. After a bite by an infected Anopheles mosquito occurs, Plasmodium sporozoites reach their target organ, the liver, within minutes. After traversing several hepatocytes, the parasite invades a final one and establishes a parasitophorous vacuole, where it replicates exponentially generating thousands of infective merozoites, the red blood cell infectious forms that are released in the blood stream. The liver stage is the first obligatory phase of malaria infection and, although no symptoms are associated with it, it is absolutely crucial to the establishment of a successful infection.(...) | por |
| dc.identifier.tid | 101260172 | |
| dc.identifier.uri | http://hdl.handle.net/10362/14121 | |
| dc.language.iso | eng | por |
| dc.title | the liver endoplasmic reticulum in malaria liver infection | por |
| dc.title.alternative | a functional study of the unfolded protein response | por |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | doctoralThesis | por |
| thesis.degree.level | PhD | por |
| thesis.degree.name | Dissertation presented to obtain the PhD Degree in Celular Biology | por |