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the liver endoplasmic reticulum in malaria liver infection
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Malaria, a disease caused by Plasmodium, represents a major health problem
with a still disconcertingly high mortality rate (655 000 malaria deaths were
estimated by the World Health Organization in 2012), mainly in Africa [1].
After a bite by an infected Anopheles mosquito occurs, Plasmodium sporozoites
reach their target organ, the liver, within minutes. After traversing
several hepatocytes, the parasite invades a final one and establishes a parasitophorous
vacuole, where it replicates exponentially generating thousands
of infective merozoites, the red blood cell infectious forms that are released
in the blood stream. The liver stage is the first obligatory phase of malaria
infection and, although no symptoms are associated with it, it is absolutely
crucial to the establishment of a successful infection.(...)