Logo do repositório
 
Publicação

Unraveling the role of the RNA chaperone Hfq in the human pathogen Listeria monocytogenes: Regulation of oxidative stress response

2026-01-08Tese de doutoramento Acesso embargado
Ver registo simples
datacite.subject.fosCiências Naturais::Ciências Biológicas
dc.contributor.advisorAndrade, José
dc.contributor.advisorArraiano, Cecília
dc.contributor.authorSeixas, André Filipe Coimbra e
dc.date.accessioned2026-03-03T12:52:43Z
dc.date.available2026-03-03T12:52:43Z
dc.date.issued2026-01-08
dc.date.submitted2025-06-30
dc.description.abstract"The RNA chaperone Hfq is a well-established post-transcriptional regulator in Gram-negative bacteria, where it facilitates small RNA–mRNA interactions. However, its role in Gram-positive bacteria remains poorly understood. In this thesis, we uncover novel functions for Hfq in the human pathogen Listeria monocytogenes, the causative agent of listeriosis, a severe foodborne disease. L. monocytogenes is a facultative intracellular bacterium that must withstand oxidative stress during infection, particularly the reactive oxygen species (ROS) generated by host immune cells.(...)"eng
dc.identifier.tid101849753
dc.identifier.urihttp://hdl.handle.net/10362/200897
dc.language.isoeng
dc.relationPD/BD/146136/2019
dc.relationCOVID/BD/153306/2023
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRNA chaperone Hfq
dc.subjectGram-positive bacteria
dc.subjectoxidative stress response
dc.subjectiron homeostasis
dc.subjectListeria monocytogenes
dc.titleUnraveling the role of the RNA chaperone Hfq in the human pathogen Listeria monocytogenes: Regulation of oxidative stress responseeng
dc.typedoctoral thesis
dspace.entity.typePublication
thesis.degree.nameDissertation presented to obtain the PhD degree in Molecular Biosciences

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
PhD MolBioS_André Seixas_January 2026.pdf
Tamanho:
8.41 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
348 B
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ITQB: CGE - PhD Theses