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Unraveling the role of the RNA chaperone Hfq in the human pathogen Listeria monocytogenes: Regulation of oxidative stress response
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Orientador(es)
Resumo(s)
"The RNA chaperone Hfq is a well-established post-transcriptional regulator in
Gram-negative bacteria, where it facilitates small RNA–mRNA interactions.
However, its role in Gram-positive bacteria remains poorly understood. In this
thesis, we uncover novel functions for Hfq in the human pathogen Listeria
monocytogenes, the causative agent of listeriosis, a severe foodborne disease. L.
monocytogenes is a facultative intracellular bacterium that must withstand oxidative
stress during infection, particularly the reactive oxygen species (ROS) generated by
host immune cells.(...)"
Descrição
Palavras-chave
RNA chaperone Hfq Gram-positive bacteria oxidative stress response iron homeostasis Listeria monocytogenes