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Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression

2018-02Recensão Acesso aberto
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dc.contributor.authorLopes-Coelho, Filipa
dc.contributor.authorGouveia-Fernandes, Sofia
dc.contributor.authorSerpa, Jacinta
dc.contributor.authorSerpa, Jacinta
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblIOS Press
dc.date.accessioned2022-12-28T22:09:29Z
dc.date.available2022-12-28T22:09:29Z
dc.date.issued2018-02
dc.descriptionFunding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported through iNOVA4Health— UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia (FCT; PhD ProRegeM program, PD/BD/128337/2017)/Ministério da Educação e Ciência through national funds and co-funded by FEDER under the PT2020 Partnership Agreement.
dc.description.abstractThe way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2114694
dc.identifier.doi10.1177/1010428318756203
dc.identifier.issn1010-4283
dc.identifier.otherPURE: 3625348
dc.identifier.otherPURE UUID: 4398b737-9d9d-4000-877a-5d72af8b0006
dc.identifier.otherPubMed: 29421992
dc.identifier.otherScopus: 85042594796
dc.identifier.urihttp://hdl.handle.net/10362/146707
dc.language.isoeng
dc.peerreviewedyes
dc.subjectCancer metabolism
dc.subjectcancer-associated adipocytes
dc.subjectcancer-associated fibroblasts
dc.subjectmicroenvironment
dc.subjecttumor-associated macrophages
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMetabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progressionen
dc.typereview
degois.publication.issue2
degois.publication.titleTumor Biology
degois.publication.volume40
dspace.entity.typePublication
person.familyNameSerpa
person.givenNameJacinta
person.identifier.ciencia-id2610-7C0D-38F2
person.identifier.orcid0000-0002-1548-5907
person.identifier.ridO-8942-2014
person.identifier.scopus-author-id6601922586
rcaap.rightsopenAccess
relation.isAuthorOfPublication5f6eaca2-f01f-4894-8da2-688671913214
relation.isAuthorOfPublication.latestForDiscovery5f6eaca2-f01f-4894-8da2-688671913214

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