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Orientador(es)
Resumo(s)
The way cancer cells adapt to microenvironment is crucial for the success of carcinogenesis, and metabolic fitness is essential for a cancer cell to survive and proliferate in a certain organ/tissue. The metabolic remodeling in a tumor niche is endured not only by cancer cells but also by non-cancerous cells that share the same microenvironment. For this reason, tumor cells and stromal cells constitute a complex network of signal and organic compound transfer that supports cellular viability and proliferation. The intensive dual-address cooperation of all components of a tumor sustains disease progression and metastasis. Herein, we will detail the role of cancer-associated fibroblasts, cancer-associated adipocytes, and inflammatory cells, mainly monocytes/macrophages (tumor-associated macrophages), in the remodeling and metabolic adaptation of tumors.
Descrição
Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported through iNOVA4Health— UID/Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia (FCT; PhD ProRegeM program, PD/BD/128337/2017)/Ministério da Educação e Ciência through national funds and co-funded by FEDER under the PT2020 Partnership Agreement.
Palavras-chave
Cancer metabolism cancer-associated adipocytes cancer-associated fibroblasts microenvironment tumor-associated macrophages SDG 3 - Good Health and Well-being