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Olive Oil Industry By-Products as a Novel Source of Biophenols with a Promising Role in Alzheimer Disease Prevention

2024-10-12Recensão Acesso aberto
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dc.contributor.authorGonçalves, Marta
dc.contributor.authorCosta, Marlene
dc.contributor.authorPaiva-Martins, Fátima
dc.contributor.authorSilva, Paula
dc.contributor.institutionInstituto de Comunicação da NOVA (ICNOVA)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-02-05T21:21:06Z
dc.date.available2025-02-05T21:21:06Z
dc.date.issued2024-10-12
dc.descriptionUIDB/05021/2020 UIDP/05021/2020 UIDB/50006/2020
dc.description.abstractThis review explores the potential health benefits and applications of phenolic secoiridoids derived from olive oil by-products in the prevention of Alzheimer’s disease (AD). As reviewed herein, polyphenols, such as epigallocatechin-3-gallate, epicatechin, and resveratrol, show in vitro and in vivo antioxidant, anti-inflammatory, and neuroprotective properties, and are particularly relevant in the context of AD, a leading cause of dementia globally. The olive oil industry, particularly in the Mediterranean region, produces significant amounts of waste, including leaves, pomace, and wastewater, which pose environmental challenges but also offer an untapped source of bioactive compounds. Despite promising in vitro and in vivo studies indicating that olive-derived polyphenols, such as oleuropein and hydroxytyrosol, may mitigate AD pathology, human clinical trials remain limited. The variability in extraction methods and the complex nature of AD further complicate research. Future studies should focus on standardizing the protocols and conducting robust clinical trials to fully assess the therapeutic potential of these compounds. This approach not only supports the development of new treatments for AD but also promotes environmental sustainability by valorizing olive oil industry waste.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent60
dc.format.extent3465226
dc.identifier.doi10.3390/molecules29204841
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 108774349
dc.identifier.otherPURE UUID: bca70e58-024b-45da-97f2-b3212d0b8811
dc.identifier.otherScopus: 85207684594
dc.identifier.otherPubMed: 39459209
dc.identifier.urihttp://hdl.handle.net/10362/178506
dc.identifier.urlhttps://www.scopus.com/pages/publications/85207684594
dc.identifier.urlhttps://www.mdpi.com/1420-3049/29/20/4841
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05021%2F2020/PT
dc.relationNOVA Institute of Communication
dc.relationNOVA Institute of Communication
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectAlzheimer’s disease prevention
dc.subjectHydroxytyrosol
dc.subjectMediterranean diet
dc.subjectNeuroprotection
dc.subjectPleuropein
dc.subjectOlive oil by-products
dc.subjectPhenolic compounds
dc.subjectPolyphenols
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleOlive Oil Industry By-Products as a Novel Source of Biophenols with a Promising Role in Alzheimer Disease Preventionen
dc.typereview
degois.publication.firstPage1
degois.publication.issue20
degois.publication.lastPage60
degois.publication.titleMolecules
degois.publication.volume29
dspace.entity.typePublication
oaire.awardNumberUIDB/05021/2020
oaire.awardNumberUIDP/05021/2020
oaire.awardNumberUIDB/50006/2020
oaire.awardTitleNOVA Institute of Communication
oaire.awardTitleNOVA Institute of Communication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05021%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05021%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication644a17ef-9379-4935-b15f-e1f0f30f3a09
relation.isProjectOfPublication0b5e5093-06ac-4c4e-8679-f447a078f103
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication.latestForDiscovery644a17ef-9379-4935-b15f-e1f0f30f3a09

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