Publicação
How mitotic transcription inactivation can modulate cell fate and cell identity
| datacite.subject.fos | Ciências Naturais::Ciências Biológicas | |
| dc.contributor.advisor | Oliveira, Raquel | |
| dc.contributor.advisor | Duque, Paula | |
| dc.contributor.author | Pedro, Catarina Alxandra Dinis de Andrade | |
| dc.date.accessioned | 2026-05-14T16:21:52Z | |
| dc.date.available | 2026-05-14T16:21:52Z | |
| dc.date.issued | 2026-04-27 | |
| dc.date.submitted | 2025-12-21 | |
| dc.description.abstract | "Upon entry into mitosis, transcriptional activity is sharply decreased. For many years, this decrease was viewed mainly as a passive consequence of chromosome condensation, which was thought to block access of the transcription machinery to DNA. However, it is now clear that the highly condensed, X-shaped mitotic chromosomes can still be compatible with transcription. Therefore, the question of why cells shut down transcription during mitosis remains. In order to proliferate, cells need to progress through mitosis fulfilling all the checkpoints required, ensuring mitotic fidelity and proper segregation of chromosomes to the two daughter cells. Similarly, transcriptional programs also need to be transmitted across mitosis. Regulators such as “mitotic bookmarkers” ensure such transcriptional programs and cellular identity propagation.(...)" | eng |
| dc.identifier.tid | 101858680 | |
| dc.identifier.uri | http://hdl.handle.net/10362/203099 | |
| dc.language.iso | eng | |
| dc.relation | UI/BD/152250/2021 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | mitosis | |
| dc.subject | cells | |
| dc.subject | chromatin regulators | |
| dc.subject | TTF2 | |
| dc.title | How mitotic transcription inactivation can modulate cell fate and cell identity | eng |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| thesis.degree.name | Dissertation presented to obtain the PhD degree in Integrative Biology and Biomedicine |