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How mitotic transcription inactivation can modulate cell fate and cell identity
| Nome: | Descrição: | Tamanho: | Formato: | |
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| 27.28 MB | Adobe PDF |
Orientador(es)
Resumo(s)
"Upon entry into mitosis, transcriptional activity is sharply decreased. For
many years, this decrease was viewed mainly as a passive consequence of
chromosome condensation, which was thought to block access of the
transcription machinery to DNA. However, it is now clear that the highly
condensed, X-shaped mitotic chromosomes can still be compatible with
transcription. Therefore, the question of why cells shut down transcription
during mitosis remains. In order to proliferate, cells need to progress through
mitosis fulfilling all the checkpoints required, ensuring mitotic fidelity and
proper segregation of chromosomes to the two daughter cells. Similarly,
transcriptional programs also need to be transmitted across mitosis.
Regulators such as “mitotic bookmarkers” ensure such
transcriptional programs and cellular identity propagation.(...)"
Descrição
Palavras-chave
mitosis cells chromatin regulators TTF2