Publicação
Exploring induced pluripotent stem cell derived 3D neural cultures to model Mucopolysaccharidosis type VII
| dc.contributor.advisor | Brito, Catarina | |
| dc.contributor.advisor | Terasso, Ana Paula | |
| dc.contributor.author | Painho, Beatriz | |
| dc.date.accessioned | 2024-10-22T17:19:18Z | |
| dc.date.available | 2024-10-22T17:19:18Z | |
| dc.date.issued | 2019-12 | |
| dc.description.abstract | "Mucopolysaccharidosis type VII (MPSVII) is an ultra-rare lysosomal storage disease, occurring due to mutations in the gene encoding β-glucuronidase, one of the enzymes responsible for the step-wise degradation of glycosaminoglycans. Enzyme deficiency leads to intralysosomal accumulation of partially degraded glycosaminoglycans in many tissues, including the brain. Currently, the link between endosomal-lysosomal system dysfunction and neurological symptoms remains unclear.(...)" | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10362/173894 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Instituto de Tecnologia Química e Biológica António Xavier | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Mucopolysaccharidosis type VII | pt_PT |
| dc.subject | 3D cell culture | pt_PT |
| dc.subject | neural differentiation | pt_PT |
| dc.subject | neurospheroids | pt_PT |
| dc.subject | human induced pluripotent stem cell | pt_PT |
| dc.title | Exploring induced pluripotent stem cell derived 3D neural cultures to model Mucopolysaccharidosis type VII | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Oeiras, Portugal | pt_PT |
| person.familyName | Carones Painho | |
| person.givenName | Beatriz Alexandra | |
| person.identifier.ciencia-id | 3814-CFE6-6237 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| relation.isAuthorOfPublication | 6ce70c1e-b69b-4a90-aacc-b5b46ff9698f | |
| relation.isAuthorOfPublication.latestForDiscovery | 6ce70c1e-b69b-4a90-aacc-b5b46ff9698f |