ITQB: BC - PhD Theses
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- Synthesis of phenolic compounds from virgin olive oil and their biological evaluationPublication . Martins, B.T.; Ventura, Rita"In recent years, investigating the bioactive compounds from natural sources, and their synthesis, has garnered significant attention due to their biological benefits. Among these, the phenolic compounds in extra virgin olive oil (EVOO) have been recognised for their diverse biological activities, including antioxidant, anti inflammatory and antiproliferative effects. This thesis delves into the synthesis, stability and biological evaluation of hydroxytyrosol (HT) and its derivatives, as well as the development of innovative synthetic strategies for the obtention of oleocanthal and oleacein, two other important phenolic compounds in EVOO. One of the main goals of this research was to develop efficient and scalable synthetic methods for HT and its derivatives, as detailed in Chapter 2. This chapter presents novel approaches for the regioselective synthesis of HT glucuronides and sulfates, overcoming challenges related to regioisomeric mixtures and paving the way for further biological studies."
- Development of new thiourea organocatalysts for asymmetric reactionsPublication . Rénio, Márcia; Ventura, Maria Rita; Murtinho, Dina"Nowadays it is almost impossible to find a synthesis of a natural product or drug candidate that does not use a catalyst. Typically, catalysts used in organic synthesis are metal compounds; however the use of other catalytic methods has been increasing, namely organocatalysis. This type of catalysis describes the acceleration of chemical reactions through the addition of a substoichiometric quantity of an organic compound that does not contain a metal atom. A growing number of publications has appeared in this area, describing not only the application of known organocatalysts for new reactions but also the development of new organocatalysts. The potential of this research area was recognised in 2021, when the Nobel prize Chemistry was awarded to Benjamin List and David MacMillan for their efforts on the development of asymmetric organocatalysis, a new precise tool for molecular construction. (...)"
- Synthesis of new enzyme stabilisers inspired by compatible solutes of hyperthermophilic microorganismsPublication . Lourenço, Eva Correia; Ventura, Rita; Santos, HelenaIn response to osmotic or heat stress, marine hyperthermophiles (thriving optimally at or above 80ºC) accumulate ionic compatible solutes such as α-Dmannosyl- D-glycerate (MG). It has been proposed that these hypersolutes stabilise intracellular components, such as proteins and enzymes, allowing them to withstand high growth temperatures.(...)