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- Manipulation of the Centrosome-Cilia complex by virusesPublication . Dias, Camila Fernandes Mariano; De Tecnologia Química e Biológica António Xavier, Instituto; NOVA de Lisboa, Universidade"Centrosomes are the main microtubule organising centres (MTOCs) in most animal cycling cells, and they are composed of an orthogonally arranged pair of centrioles surrounded by a matrix of proteins, called the pericentriolar material (PCM). Microtubules form a highly dynamic network, most often anchored and organised by the centrosome, which radiates throughout the cell and regulates the transport of cargo. As obligate intracellular parasites, viruses have evolved multiple strategies to exploit the host cell machinery in order to comply with their life cycles. Amongst these, interactions with the host cell cytoskeleton, including with the microtubule network, are widely established as a means for viruses to reach replication or assembly sites, as well as to egress from cells.(...)"
- A dual function of SnRK2 kinases in the regulation of SnRK1 and plant growthPublication . Belda-Palazón, Borja; Adamo, Mattia; Valerio, Concetta; Ferreira, Liliana J.; Confraria, Ana; Reis-Barata, Diana; Rodrigues, Américo; Meyer, Christian; Rodriguez, Pedro L.; Baena-González, Elena; Bioresources 4 Sustainability (GREEN-IT); Nature ResearchAdverse environmental conditions trigger responses in plants that promote stress tolerance and survival at the expense of growth1. However, little is known of how stress signalling pathways interact with each other and with growth regulatory components to balance growth and stress responses. Here, we show that plant growth is largely regulated by the interplay between the evolutionarily conserved energy-sensing SNF1-related protein kinase 1 (SnRK1) protein kinase and the abscisic acid (ABA) phytohormone pathway. While SnRK2 kinases are main drivers of ABA-triggered stress responses, we uncover an unexpected growth-promoting function of these kinases in the absence of ABA as repressors of SnRK1. Sequestration of SnRK1 by SnRK2-containing complexes inhibits SnRK1 signalling, thereby allowing target of rapamycin (TOR) activity and growth under optimal conditions. On the other hand, these complexes are essential for releasing and activating SnRK1 in response to ABA, leading to the inhibition of TOR and growth under stress. This dual regulation of SnRK1 by SnRK2 kinases couples growth control with environmental factors typical for the terrestrial habitat and is likely to have been critical for the water-to-land transition of plants.