A carregar...
Publicação
Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-κB) p65/RelA
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 14.46 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Living in an ever-changing environment, cells have evolved numerous
mechanisms that allow their assessment of the environment, their
communication with each other and the integration of the information in
order to adapt to the environmental changes and to maintain their
homeostasis. In the presence of harmful stimuli, such as infection or
tissue damage, a series of defensive sequential events, including the
activation of vascular endothelial cells (EC), are initiated and result in the
inflammatory stress response. Much of the inflammatory response is
regulated at the level of gene transcription through the expression of a
number of proinflammatory genes such as adhesion molecules and
stress-responsive cytoprotective genes, e.g. heme oxygenase 1 (HO-1).(...)
Descrição
Dissertação para a obtenção do grau de doutor em Biologia pelo Instituto de Tecnologia Química e Biológica. Universidade Nova de Lisboa.
Palavras-chave
Contexto Educativo
Citação
Editora
Instituto de Tecnologia Química e Biológica. Universidade Nova de Lisboa